A historical cohort study of eosinophilic inflammation in chronic rhinosinusitis with nasal polyps in Okayama, Japan
نویسندگان
چکیده
Background CRSwNP(Chronic rhinosinusitis with nasal polyps) is characterized with eosinophil infiltration into sinonasal tissues in Caucasian patients. In Japan, this condition was thought to be an infectious disease (so called “empyema”) for a long time. However, after a clinical profile of ECRS(eosinophilic chronic rhinosinusitis) was first introduced by Moriyama in 2002, the prevalence of ECRS in CRSwNP seems to be increasing in clinical setting. In the present study, we examined a historical cohort study and determined the alteration of eosinophilic inflammation in sinonasal tissues in Japanese CRS.
منابع مشابه
Comparison of Expression of Cytokeratin 7 on Epithelium of Nasal Polyps and Mucosa of Chronic Rhinosinusitis
Background and Objective: Nasal polyp is the most common benign mass of the nasal cavity and it is originated from nasal cavity or sinuses. Cytokeratins (CK) are intermediate filament proteins that provide mechanical support in epithelial cells. The purpose of this study was to compare the expression of cytokeratin 7 in epithelium of nasal polyps and nasal mucosa in chronic rhinosinusitis. Mate...
متن کاملEosinophilic Mucin Rhinosinusitis in Iranian Patients Undergoing Endoscopic Sinus Surgery
Introduction: Eosinophilic mucin rhinosinusitis is a type of chronic rhinosinusitis (CRS). Diagnosis and treatment of this condition play a significant role in reducing the patients’ clinical symptoms. This type of rhinosinusitis has a higher relapse rate, compared to the other types. This disease is more resistant to treatment and more dependent on corticosteroid therapy, compared to the oth...
متن کاملT-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients
BACKGROUND Chronic rhinosinusitis with nasal polyps is characterized by local inflammation and is categorized into two subtypes in Japan: eosinophilic chronic rhinosinusitis, and non-eosinophilic chronic rhinosinusitis. The objective of this study was to investigate the expression of key transcription factors for Treg and Th1/Th2/Th17 cells, in relation to the mRNA expression of representative ...
متن کاملEpidemiology and differential diagnosis of nasal polyps
BACKGROUND Chronic rhinosinusitis (CRS) is one of the most common chronic medical conditions, with a significant impact on patient quality of life. CRS is broadly classified into two groups: CRS with nasal polyposis (CRSwNP) and CRS without NP (CRSsNP). Clinically, the major subtypes of CRSwNP may be divided into eosinophilic chronic rhinosinusitis (e.g., allergic fungal rhinosinusitis and aspi...
متن کاملEmerging Role of Proteases in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous upper airway disease with multiple etiologies. Clinically, CRSwNP can be classified into either eosinophilic or non-eosinophilic subtypes. The eosinophilic phenotype of CRSwNP is widely thought to be highly associated with recurrence of nasal polyps or surgical failure. Epithelial cells have a crucial role in the development o...
متن کامل